Monocytes in Neonatal Bacterial Sepsis: Think Tank or Workhorse?

Infection and sepsis remain among the leading causes of neonatal mortality. The susceptibility newborns to infection can be attributed their immature immune system. Regarding response, monocytes represent a numerically minor population leukocytes. However, they contribute variety immunological demands, such as continuous replenishment resident macrophages under non-infectious conditions migration inflamed sites where neutralize pathogens secrete cytokines. Further functions include presentation antigens T-cell activation. Cytokines coordinate host responses bacterial viral infections orchestrate ongoing physiological signaling between cells non-immune tissues. A critical event is skewing cytokine repertoire achieve resolution infection. In this regard, may hold key position deciders in addition phagocytic activity, securing extinction prevent broader organ damage by toxins pro-inflammatory reactions. Neonatal undergo various regulatory metabolic changes. Thus, are thought vulnerable anticipating cause severe progressions which increase risk developing sepsis. Furthermore, clinical studies have shown that exposure inflammation puts neonates at high for adverse pulmonary, other developments, result multiorgan disease. This review discusses significant impairments decisive outcome infections.